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Job Field: Security
Location: San Diego, CA
Salary: $Not stated

JOB SUMMARY:

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<tr><td valign="top" width="450"><b>Job Title Associate Director, Discovery Toxicology (Drug Safety Evaluation)Req ID 4386BRDepartment Drug Safety EvaluationLocation San Diego, CAJob Description Vertex Pharmaceuticals is seeking an Associate Director, Discovery Toxicology (Drug Safety Evaluation) to design and lead strategies for the early safety assessments of Vertex Discovery Compounds and will be located in our state of the art Research Center in San Diego, CA. Drug Safety Evaluation (DSE) is a global function responsible for the design and conduct of preclinical safety programs for the comprehensive safety assessment of Vertex therapies at all stages of discovery and development. Vertex Pharmaceuticals uses cutting edge science and technologies to perform robust assessments of novel therapies for the treatment of the most serious diseases with unmet medical need.  Our culture enables individual empowerment where We Wins" Fearless Pursuit of Excellence" and Innovation" are more than just corporate values: They are part of our everyday lives.DSE members have significant roles in the drug development process beginning in the early drug discovery phases and continuing through the entire drug development process resulting in registration and marketing. Key Responsibilities: - In partnership with our San Diego research colleagues, advise, strategically plan, and manage San Diego discovery toxicology programs to facilitate lead optimization. As compounds progress through the development pipeline, close interactions with Cambridge toxicologists will enable timely progression into first in human studies.- Attend San Diego driver team meetings and assist in template or compound selection based upon early safety assessments. - Along with the Global Discovery Support Team, perform early safety assessments of Vertex discovery compounds in order to identify potential developmental challenges and strategies to address these challenges.- Establish a culture of ownership and deep scientific involvement and build strong cross-site collaborations between Drug Safety Evaluation and discovery teams in San Diego.- Along with the Head of Discovery Toxicology, assist in developing a strategic vision for the role of multisite Discovery Toxicology within Vertex and implement this vision with selective use of new and established technologies to deliver efficient de-risking and investigational endpoints for current therapeutic leads.- Enhance collaborations with discovery scientists across sites and advise on benchmarking and implementation of state of the art in silico, in vitro and in vivo technologies critical for selection and optimization of Vertex compounds for further development. - Communicate unambiguous critical and significant project information to various bodies including project teams and Vertex leadership as required.- Build strong scientific collaborations with external groups within both the academic and industrial sectors with the intent of enhancing Vertex's discovery toxicology capabilities.- Collaborate on design of investigative toxicology studies in support of development compounds.Minimum Qualifications Minimum Qualifications:- Ph.D. in Toxicology- Seven years or more experience in the Pharmaceutical Industry with proven abilities within the Discovery Toxicology/Investigative Toxicology arena for predictive safety assessments.- Demonstrated working knowledge of drug development principles.- Proven ability to creatively seek resolutions to issues of predictive toxicology.- Strong problem solver who is highly organized with the ability to thrive and to lead in an environment with rapidly changing priorities.- Strong interpersonal and collaboration skills with proven ability to work effectively on multi-disciplinary project teams.Preferred Qualifications:- DABT Board certification preferred.- Experience in the use of Stem Cells for predictive safety assessments or experience in immunotoxicology or CNS related disease preferred but not required.Company Information V

KEY REQUIREMENTS:

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